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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Fetoni A.R., Paciello F., Rolesi R., Paludetti G., Troiani D

If you take metformin, your physician may recommend: More frequent blood glucose monitoring during the first 2 to 4 weeks of MOTS-c use Starting MOTS-c at a lower dose (2.5 mg rather than 5 mg) Watching for signs of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat Potential metformin dose adjustment as MOTS-c's effects take hold Insulin MOTS-c improves glucose uptake in skeletal muscle independently of insulin

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Research indicates that following cerebral ischemia, antioxidant enzyme levels significantly de-crease, reactive oxygen species (ROS) production increases, and excessive deposition of amyloid-beta (A) proteins occurs (47)