napqi glutathione mechanism What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)? 3️⃣ Glutathione Rescue Normally, glutathione
3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Current concepts of experimental acetaminophen (APAP) Download Scientific Diagram Biotransformations Leading to Toxic Metabolites: Chemical Aspects ScienceDirect SUPER EASY MEMORY Too much Tylenol More NAPQI Less glutathione Liver dies NAC More glutathione Liver saved First line treatment for acetaminophen overdose: A. Flumazenil B. Naloxone C. N acetylcysteine D. Sodium bicarbonate
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