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G., Hardan, A., Vagnucci, A., Pollock, B., Luther, J., Buttenfield, J., Verfaille, S., & Kupfer, D

Studies have found that oral administration of puerarin (10 mg/kg and 50 mg/kg) could improve the general symptoms and disease activity of DSS-induced UC, possibly through down-regulating the levels of inflammatory cytokines like TNF-, IL-1 and IL-6, transcription factor NF-B, and other factors such as COX-2, PGE2, NO [250]

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As mentioned, the specific issue could be a strong effect on increasing angiogenesis, increased VEGF, increased egr-1 gene, increased NO, or eNOS stimulation and counteraction of increased free radical formation

Lahiguera , Hyroov P, Figueras A, et al