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In summary, ubiquitination regulates the initiation, progression, and termination of DDR, and controls the switch between different types of cellular responses, which makes DDR an elegant and accurate machinery

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NORSE and FIRES are defined below: Epilepsia partials continua (EPC) is defined & discussed here: NORSE NORSE definitions New-onset Refractory Status Epilepticus (NORSE) : New-onset seizure with refractory status epilepticus (i.e., refractory to two medications such as benzodiazepine plus levetiracetam)