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It may influence digestion indirectly by supporting gut barrier health, but it is not a laxative

Specifically, knockdown of NNT resulted in elevations in cellular and mitochondrial NADH/total NAD(H) and decreases in cellular and mitochondrial NADPH/total NADP(H) with a concomitant increase in mitochondrial O 2 production, indicating that NNT silencing induces reductive stress in these cells (33)

They also rapidly deplete antioxidants like glutathione, our master antioxidant, as well as vitamins A, C, and E

The condition often coexists with other issues like high blood pressure, elevated cholesterol levels, and inflammation, all of which are detrimental to heart health

Preoperative short-term calorie restriction for prevention of acute kidney injury after cardiac surgery: a randomized, controlled, open-label, pilot trial