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Conversely, insulin resistance stimulates ovarian and adrenal androgen production through multiple mechanisms, creating a self-perpetuating pathogenic cycle (10)

PLoS One 20:e0314029

The GCLM subunit has no enzymatic activity but has an important regulatory function increasing the efficiency of the GCLC subunit

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An alternative approach to diagnosis is to wait until the hemolytic crisis is over and reevaluate the patient after the red blood cell mass is repopulated with cells of all ages (approximately 2 to 3 months)