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It was observed that treatment with ALA led to a stabilization of cognitive functions demonstrated by constant scores in two neuropsychological tests (the Mini-Mental State Examination and the cognitive subscale of the AD assessment score)

It is important to mention that although the elderly group receives a small dose of CoQ10, it is administered in conjunction with transcutaneous electrical acupoint stimulation ( In vitro studies have demonstrated that the addition of 50 M CoQ10 to the culture medium resulted in increased expression of Bcl2 and Sirt1 in cumulus cells, and a positive impact on the reduction of ROS, maturation rate, and first polar body extrusion was enhanced from 48.9% to 75.7% by the addition of CoQ10 to the culture medium (Figure 1)

In this context, Everolimus is a promising second-generation rapamycin derivative and is a specific inhibitor of mTORC1, which suppress mRNA translation, ribosome biogenesis, protein synthesis, mitochondrial metabolism, and adipogenesis 83

It is also useful to people who are in need of additional nutritional support