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Oxidative stress-induced DNA damage affects the coding region of mtDNA and influences oxidative phosphorylation, thereby altering the respiratory chain and unregulated production of ROS [11]

However, glutamine is a osmotically active substance, which can cause neuronal edema and disrupt neuronal metabolic homeostasis

Because it is an autoimmune condition, Hashimotos can be associated with systemic symptoms such as fatigue, brain fog, joint discomfort, and other immune-related imbalances.

However, no clear correlation was observed between the VHL status and sensitivity to BSO, or VHL status and glutathione levels in these cancer cell lines (Table II

[10] Sahm et al., 2018a