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The cytokines and oxidative stress byproducts arising from synovitis further activate synovial cells and chondrocytes to release additional inflammatory mediators and catabolic enzymes

Food & Drug Administration (FDA) FDA grants accelerated approval to elamipretide (Forzinity) as first treatment for Barth syndrome (2025) Journal of the American College of Cardiology (JACC) PROGRESSHF trial: safety and tolerability of elamipretide in heart failure patients Neurology (AAN Journals) MMPOWER2 trial: elamipretide in primary mitochondrial myopathy Genetics in Medicine (Nature) TAZPOWER trial: efficacy and safety of elamipretide in Barth syndrome Biochimica et Biophysica Acta (BBA) Bioenergetics Cardiolipin remodeling and cristae structure: role in mitochondrial function Journal of Cardiovascular Pharmacology (PMC) SS31 reduces oxidative stress and improves mitochondrial bioenergetics Alzheimers Drug Discovery Foundation Cognitive Vitality Report: SS31 (elamipretide) preclinical and clinical overview Orphanet Journal of Rare Diseases (PMC) Barth syndrome: clinical presentation, diagnosis, and emerging therapies Centers for Disease Control and Prevention (CDC) Vaccine administration: subcutaneous injection technique (angle, site selection, no aspiration) Johns Hopkins Arthritis Center Patient guide: how to give a subcutaneous injection (stepbystep instructions) NCBI Bookshelf (StatPearls) Best practices for injection: aseptic technique, preparation, and administration Pharmacologic Considerations of Subcutaneous Drug Administration (PMC) Site rotation, absorption kinetics, and prevention of lipohypertrophy Related research, protocols, and guides Explore the available research context, protocol variants or comparisons, and practical guides

In models of obese mice, BETd reduced senescent hepatic stellate cell burden and suppressed carcinogenesis

J Am Acad Dermatol , 40(6 Pt 1):930937

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