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For a longevity-focused individual making evidence-informed decisions, that distinction is the most important thing to understand

Our aim involved the use of a systematic design of experiments that tested the effect of salt, increasing buffer volume, adding a commercial solubilizing concoction (BugBuster ), using a mild detergent such as IGEPAL CA-630 and mechanical lysis using sonication

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Hayes JD, Flanagan JU and Jowsey IR: Glutathione transferases.Annu Rev Pharmacol Toxicol 2005

These effects are most consistently observed in wound and dermal models