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Extended cycles may run 12 weeks on with 6 weeks off for individuals with significant metabolic goals

No established upper limit exists because excess b12 excretes through kidneys without causing harm

10.1016/j.devcel.2024.12.011 173 PerluigiM.Di DomenicoF.ButterfieldD

Dev Rev 24(2):189233

Furthermore, HFD-induced microbiota dysbiosis disrupted the intestinal barrier, increasing gut pathogenic bacteria and circulating endotoxin, which disequilibrated the local microenvironment and caused inflammation in the lung (Chakradhar, 2017)