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Cagnin, Gerhard, and Banati [79] briefly outline the rationale for employing PET for imaging of activated microglia to detect in vivo inflammatory changes occurring in a variety of brain diseases and at different disease stages, and to monitor the progression of neuroinflammation as an in vivo marker of disease activity

And they provided the first observation that mice over-expressing ACE in macrophages have a markedly enhanced immune response to tumors and bacterial infections

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255 Oxidizing an alcohol hydroxyl group to an aldehyde or carboxyl group or converting a carboxyl group to an ester group can modulate a drugs water solubility, fat solubility, stability, and other characteristics

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