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Levels of mRNA expression of peroxisome proliferator-activated receptor (PPAR) and CCAAT/enhancer binding protein (C/EBP), two of the major transcription factors for adipogenesis [15, 16], were suppressed 4070% in WAT of HSL null mice

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IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements