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Acknowledgments The authors extend their appreciation to the Researchers Supporting Project number (RSP2024R176) King Saud University, Riyadh, Saud Arabia

Collectively, these data confirm the involvement of lipid peroxidation with increased production of the by-product MDA, and high levels of ferrous iron which are consistent with the increased susceptibility to ferroptotic cell death in CF cells

Neutrophil-derived 5-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation

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These metabolites can be easily absorbed and delivered to brain cells to improve brain health