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Additionally, as described in more detail later in this final rule with comment period, we are delaying enforcement of these new requirements to April 1, 2026 to allow hospitals additional time to implement the requirements

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Each 4-week block gives the GLP-1, GIP, and glucagon receptors time to adjust, which significantly reduces the nausea, vomiting, and diarrhea that many researchers experience during dose increases

These changes were accompanied by a decrease in norepinephrine and an increase in serotonin levels in the prefrontal cortex and hippocampus