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A meta-analysis of seven studies including 1,757 participants with type 2 diabetes found that SGLT2 inhibitor therapy in combination with blood pressure medications (known as renin-angiotensin system blockers) was well-tolerated and resulted in greater improvement in blood pressure, glucose control, body weight, and indices of kidney function compared with the blood pressure drugs alone (Tian 2021)

These pharmacokinetic constraints highlight a translational gap between experimental conditions and clinically attainable dosing regimens

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