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Groenberg H

[224] demonstrated that oxidative stress triggers mtDNA leakage, which activates the cGASSTING pathway and induces the secretion of pro-inflammatory cytokines in human iPSC-derived neurons

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Ann Rheum Dis 79:685699

Heterozygous PPAR-deficient mice were protected from the development of insulin resistance under a HF diet, because the presence of more small adipocytes led to a reduction in the secretion of these molecules 41