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doi: 10.1016/j.redox.2019.101418 103 ZhouBLiuJKangRKlionskyDJKroemerGTangD

The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

Although this region of the enzyme has been confirmed to bind GSH and the C28-C31 pair has been observed to be necessary for the reduction of GSSG, there is no explicit evidence of how electrons are transmitted to the GR domain

Mechanistically, NAMPT can also regulate stemness in a paracrine manner through the senescence-associated secretory phenotype

Grouping of features was set to those present in at least 25% of all samples (retention time deviation 10 s