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Patients lacking intrinsic factor, those with gastrointestinal surgery, or severe neurological symptoms benefit most from injections

This is normally adequate to maintain proper hydration, but when recovering from general anesthesia, your needs may be higher

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A more recent study by Jiang et al

The oxidative stress, typically observed in pathological conditions determining endothelial dysfunction, might induce endothelial NO depletion and reduced endothelial NO availability, mediated by the interaction of reactive oxygen species with NO to generate oxidative agents potentially damaging cell DNA and proteins, namely reactive nitrogen-containing species [51], or by a direct decrease of NO synthesis, therefore suggesting potential benefit from the administration of NOS substrates, such as l-ARG, as a therapeutic strategy to increase NO production and improve CVD-related endothelial dysfunction [19, 52]