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In studies of brain injury models, overexpression of GPX1 can improve spatial learning ability after brain injury in young mice compared with wild-type mice, possibly due to overexpression of GPX1, which reduces oxidative damage in mice at an early stage (Tsuru-Aoyagi et al., 2009)

& Sumitomo, S

Computational models are integrative platforms to simulate these multilevel alterations, enabling in silico testing of hypotheses that inform personalized therapeutic interventions

These findings highlight the intricate interplay between mechanosensitive and heat-sensitive channels in the PNS and CNS, suggesting Piezo2 as a potential therapeutic target for visceral pain treatment

Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, et al