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When introducing a new supplement, we recommend taking the lowest dose for 2-3 days

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Renal dosing adjustments for adult patients (18 years and older) with cIAI and cUTI with CrCl 50 mL/min or less a,b a,b 30 to 50 CrCl (mL/min) 750 mg (500 mg and 250 mg) intravenously every 8 hours 15 to 29 CrCl (mL/min) 375 mg (250 mg and 125 mg) intravenously every 8 hours For patients with end-stage renal disease (ESRD) on hemodialysis (HD): a single loading dose of 750 mg (500 mg and 250 mg) followed by a 150 mg (100 mg and 50 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis)

Yeah, they make their way up the river