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11.1 Precision medicine and multi-omics integration in Alzheimer's disease While multi-omic investigations have transformed oncology over the past decade, their application in AD is still in its early stages (265)

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It is unclear whether these membranes exhibit mTORC2 activity in the cellular setting or contribute to the phosphorylation of mTORC2 substrates

ROS also enhance their proliferation via two mechanisms: either by damaging biological molecules, leading to gene mutation and inflammation, or through abnormal oxidative stress redox signaling, which distorts signaling pathways and drives cancer progression

Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer