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Description

semaglutide is stabilized against degradation by the DPP-4 enzyme

Gourine, A

The simulated interaction (AUCR, 1.28) was within ~10% of the observed interaction (AUCR, 1.39), indicating that the observed inhibition was mediated primarily by mitragynine and partly by other alkaloids shown to inhibit CYP3A in vitro , including paynantheine and speciogynine