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As such, this review highlights the urgent need for clinical trials targeting antiangiogenic therapies in neurodegenerative diseases, because without robust data from clinical studies, the efficacy and safety of such interventions remain speculative

Research protocols studying this combination aim to maximize GH pulse magnitude while preserving pulsatility an area of active preclinical investigation

Abrupt discontinuation should be avoided because it may precipitate rebound sympathetic activation, catecholamine surge, and severe rebound hypertension

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