Semax An ACTH(4-10) analog originally developed for stroke recovery research
This work was supported by the National Natural Science Foundation of China (82370364, 82274071, 82300414, and 82170424), Jiangsu Province Excellent Youth Foundation (BK20240204), Jiangsu Natural Science Foundation (BK20231049, BE2020634 and BK20191138), Joint research project of the Chinese Society of Traditional Chinese Medicine, high-level introduction of talents and scientific research start-up funds of JNU (1286010241222100), the Fundamental Research Funds for the Central Universities (JUSRP124036), Medical Discipline Program of Wuxi Health Commission, the Science and Technology Projects of Wuxi City (M202207, BJ2023029), Clinical Research and Translational Medicine Research Program of Affiliated Hospital of Jiangnan University (LCYJ202306, LCYJ202226), Wuxi Science and Technology Development Fund Project Light of the Taihu Lake (K20221028), Wuxi Municipal Health Commission Youth Project (Q202226), Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (HB2023045, BJ2023045, BJ2023029)
Half-life & zero-order kinetics : Phenytoins metabolism is saturable , resulting in zero-order kinetics (a fixed amount of the drug is cleared regardless of the drug level)
C., Baader, W
Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects.
