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Some trials report modest or non-statistically significant results

Cancer Res 60 : 23232330 Das KC, White CW (1997) Activation of NF- B by antineoplastic agents

The ratio itself never changes

Lazzara, M

For example, inhibition of the Notch pathway via -secretase inhibitors can lead to compensatory activation of the PI3K/AKT axis, preserving CSC survival