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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

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The research team is composed of a clinical assistance group of 169 general practitioners and nurses, and a technical group of 22 health professionals including doctors of different specialities, nurses and pharmacists

Folate is converted into its active form (5-methyltetrahydrofolate) through the folate cycle, and MTHFR is directly responsible for the creation of folates active form

Real Peptides synthesizes both compounds using small-batch, sequence-verified processes that guarantee purity and consistency across research batches