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Targeting cancer vulnerabilities with high-dose vitamin C

Our proposed receptor activation mechanism also suggests that the conformation of a GHSR ligand around the E124 3.33 -R283 6.55 salt bridge in the cavity II is an important structural determinant for ligand efficacy, providing a molecular foundation for designing novel ghrelin agonists

It also increases vagal tone at the AV node, slowing conduction and prolonging the refractory period (11)(56)(58)

doi: 10.1016/j.nbd.2023.106269 46 VosP

It is a water-soluble vitamin that is essential for the normal functioning of the brain, nervous system, and the formation of blood cells