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During disease progression, the accumulation of aberrant proteins can overwhelm the cellular chaperone system, as the demand for refolding and clearance exceeds its capacity 97

Pharmacological and Therapeutic Effects of Berberis Vulgaris and its Active Constituent, Berberine

This is why it's fun to do this with a scientist, 'cause they're like- Dr

Selective inhibition of a single pathway can often trigger compensatory activation of alternative signaling pathways, ultimately decreasing therapeutic efficacy [245,246,247,248,249,250]