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In c-myc -transformed cells, glutamine deprivation could disrupt the TCA cycle and induce cell death, which can be rescued by the addition of oxaloacetate or -ketoglutarate [33]

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In tissues with nucleated cells, the less stable G6PD can be replenished through synthesis of newG6PDprotein.Replenishment is not an option in red blood cells, so the protein is depleted with time, generating cells that are hypersensitive to oxidative damage

doi: 10.1186/s13063-017-2390-9 168

[DOI] [PubMed] [Google Scholar] 5.Galicia-Garcia U., Benito-Vicente A., Jebari S., Larrea-Sebal A., Siddiqi H., Uribe K.B., Ostolaza H., Martn C