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Caloric restriction

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Such results reinforce the notion that polyphenol-derived prebiotics can regulate pathogenic and commensal bacteria, strengthen hostmicrobe interactions, and ultimately contribute to improved health outcomes ( Similarly, it was found that the administration of syringaresinol modulated the gut microbiota by increasing the relative abundance of the Lactobacillus and Bifidobacterium species while decreasing levels of the potentially harmful Akkermansia genus

For example, curcumin, an extract from the rhizome of the plant Curcuma longa mentioned above, inhibits ROS production and degrades KEAP1 to activate the NRF2/ARE pathway [455]

Certainly, an increase in IGF-1 action is associated with greater risk for neoplastic disease, a link further supported by this study and others targeting IGF-1Rs, but IGF-1 has been paradoxically associated with protection against osteoporosis, type 2 diabetes, cerebrovascular and cognitive decline in pre-clinical studies, as well as in some human epidemiologic studies 12