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However, their modest efficacy in solid tumors, coupled with metabolic side effects such as insulin resistance and immunosuppression, highlights the need for more selective and context-dependent modulators

Iron treatment prescribed to anemic women with hypothyroidism has been demonstrated to improve thyroid hormone levels, and the combination of thyroxine and iron proved more effective in improving iron status in this population group [58]

In critical situations, the reduction in plasma glutamine concentration affects the redox state and the metabolism of cells of the immune system, resulting in compromised immune response contributing to the development of sepsis

In contrast, reduced and oxidized glutathione added to blood samples, cells or plasma remained intact

Prx5 protects against ferroptosis in bladder cancer, where it is also a potential biomarker [166] , colorectal cancer cells [167] , and cisplatin-induced ferroptosis leading to acute kidney injury [168]