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Estrogen replacement reverses endothelial dysfunction in postmenopausal women

For ion homeostasis there is a need for a constant membrane potential and cell volume as well as to regulate intracellular Na + and K + ions essential for the activity of several enzymes in the cytosol (Farooq et al., 2015)

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Therefore, the precise utilization of estrogen metabolites in relation to the duration of hypoxia indicates that exogenous estrogen therapy may yield superior outcomes with significant clinical implications