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It has shown favorable prophylactic effects in children aged 510 years with migraine and is well tolerated, with few side effects and no serious adverse events reported during long-term use (95, 96)

Additionally, it was shown that P53, a significant gene in tumor suppression, has the ability to reduce SLC7A11 expression to inhibit cystine uptake by system x c , thereby impairing the activity of GPX4 and leading to decreased antioxidant capacity, ROS accumulation, and ferroptosis (47)

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D-Serine levels have been shown to be progressively increased in the spinal cord of G93A mSOD1 Tg mice (Sasabe et al., 2007, 2012)