10.17219/acem/154658 79 ZhangZ.YangK.MaoR.ZhongD.XuZ.XuJ.et al (2022)
All authors contributed to the article and approved the submitted version
Because they're unstable, they can take electrons from other cells or react negatively with the molecules in a cell, setting off a chain reaction that terminates in apoptosis, or cell death.11 Oxidative stress can stem from various causes, such as smoking, drinking, environmental pollution, exposure to sunlight, and mental/physical stress.12 Although the body needs pro-oxidants, they can cause several detrimental health effects when present in overabundance without enough antioxidants to counter them, such as:13 Cancer Rheumatoid arthritis Kidney diseases Cardiovascular diseases Neurological diseases Respiratory diseases Psychological disorders Age-related degeneration Insider Tip: Glutathione is pronounced glu-ta-THI-one, with the stress on the third syllable
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INTRODUCTION As one of the driving forces behind the cellular detoxification machinery, glutathione S -transferases (GSTs) and especially the pi class glutathione S -transferase P1 (GSTP1) is currently in the focus of the cancer research community, evaluating the relevance of GSTP1 epimutations for cancer development and its potential as a major epigenetic cancer biomarker
