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Furthermore, thiazolidinedione derivatives (e.g., rosiglitazone and pioglitazone) demonstrate selective inhibition of ACSL4, consequently attenuating ferroptosis progression (Sheng et al., 2024)

8 Both the 2012 NIH Evidence-Based Methodology Workshop on PCOS and the 2018 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome recommend use of the Rotterdam criteria for the diagnosis of PCOS with the additional identification of the specific PCOS phenotype

reduced glutathione detoxifies reactive oxygen species such as hydrogen peroxide, preventing them from causing oxidative stress ( Figure 1 )

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