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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators

See Supplementary Table 3 for the respective compound concentrations for each probe set

The signs recognizing opioid overdose are small, constricted pinpoint pupils, falling asleep or losing consciousness, slow, weak or no breathing, choking or gurgling sounds, limp body, cold and/or clammy skin, and discolored lips and nails (Centre for Disease Control and prevention, 2023)

Notably, NAM serves as the substrate for NAD + synthesis in the salvage pathway (Pissios, 2017)

Instead of low ergothioneine levels leading to disease, maybe disease somehow leads to lower ergothioneine levels