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Nuclear factor erythroid 2-related factor 2 (Nrf2) as the key transcription factor playing an essential role in redox balance and depleted in COPD patients (Deshmukh et al., 2017), modulates the expression of approximately 100 genes functioning the state of redox, inducing the transcription of glutathione (GSH) (Osburn et al., 2006)

However, ignoring a sprained finger with the hope that it will heal on its own may lead to long-term problems, including chronic instability, weakness, stiffness, and arthritis

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13,14 Although the three TGF- isoforms are encoded by three different genes, their mature ligands show strong conservation of amino acid sequences

Such studies remind us that negative or nuanced outcomes are often the most enlightening, pushing the field forward and helping refine both scientific questions and clinical practice