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Treatment with SAFit2, a potent FKBP51 inhibitor, was found to decrease ubiquitin-positive inclusions, prevent neurodegeneration in the substantia nigra, and improve motor function in NM-SNCAWT (neuromelanin-induced in humanized -synuclein) mouse model [111]

human studies report only mild, transient side effects (occasional headache or nausea) [1] [8]

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Therefore, selecting a suitable cell model is crucial