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any of the seven commonly recognized stages thereof may be treated, symptoms thereof reversed or arrested without progression to a more severe stage, and/or the progression to more severe stages may be slowed

Approximately 2-fold decreases of these SC marker mRNA expression levels were observed upon TGF-2 stimulation in ZH-161 and ZH-305 cells, except OCT-4 in ZH-305

The American Journal of Kidney Diseases

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Quantification of MMP9 immunofluorescence determined that treatment with the SMAD3 inhibitor was able to significantly reduce MMP9 immunoreactivity in bEnd.3 cells to near basal levels (Figure 5d)