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Brain Behav Immun (1993) 7:97103.10.1006/brbi.1993.1010 127 MostafaGAAl-AyadhiLY

In addition, combretastatin disrupts the endothelial cell junction molecule (VE-cadherin) leading to vascular collapse [45] and in vivo studies show that combretastatin is able to reduce immature vessels [45, 46]

It does lead to irritation in some redness, irritation and appearance of a rash

Similarly, CPT improved motor function and reduced neuronal loss in LPS-induced PD models by balancing microglial polarization via the AKT/Nrf2/HO-1 and NF-B pathways, further underscoring the importance of microglial phenotype regulation in neuroprotection (He et al., 2021)

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