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doi: 10.3390/cancers15072076 82 AwasthiKHuangWCWeiCYHsuHYOhtaN

Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

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Synaptogenesis, the formation of new synapses, depends heavily on BDNF signaling through the ERK pathway