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As such, in 2014, the TGA undertook a complete de novo evaluation of NCEs, regardless of approval status by another NRA, resulting in duplication of regulatory efforts and processes

specifically, the addition of m6A tags might enable circRNAs to elude immune recognition by designating them as self RNA

Di Cesare Mannelli et al., 2014)

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Furthermore, as expected, our data indicate the existence of a trade-off between glutathione biosynthetic activity and cellular viability and fitness beyond a certain threshold, suggesting that an optimum should be aimed for in a possible strain engineering strategy