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Users who see no change by six months of consistent daily use are less likely to be responders (though continued use at that point doesn't carry significant risk)

Unlike metformin, which has a well-documented association with reduced vitamin B12 absorption, tirzepatide has not demonstrated a similar pharmacological mechanism that would directly interfere with B12 metabolism or absorption in the terminal ileum

So youll always look better than if you had done nothing, but of course we cant freeze time

Cagrilintide is also studied in combination with semaglutide (the investigational pairing known as CagriSema ), where trials have reported substantial weight reductions beyond either agent alone [5] [6]