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10.1016/j.pneurobio.2015.09.011 Prog

We did not find a significant non-linear relationship between dose (g/day) (coefficients = 1.72, p = 0.154) and changes in FBG, but we found a significant non-linear relationship (coefficients = 7.45, p = 0.020) between duration of intervention and changes in FBG, It seems that the effective duration for decreasing of FBG is 50 weeks (Figures 4A, 5A)

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Summarizing, by profiling the multi-pathway effects of insufficient branched-chain amino acid catabolism in MSUD patients, we were able to confirm broad changes to lipid bilayer composition and acyl-carnitine levels within patient blood samples in response to the buildup of branched-chain amino acids and their associated ketoacids