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MEFs were cultured in DMEM High Glucose medium (ECM0728L, Euroclone) supplemented with 10% inactivated FBS (ECS0180L, Euroclone), 2 mM glutamine (ECB3000D, Euroclone), penicillin (100 IU ml 1 ) and streptomycin (100 g ml 1 ) (ECB3001D, Euroclone) and maintained at 37 C with 5% CO 2

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Since clinical trial registries rely on sponsor-reported information, analyses were conducted using only available data

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy