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The creation of the small gastric pouch and the gastro-jenunal connection follows

The systemic safety profile from any meaningful absorption from a topical preparation is favorable

The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

Beneath that surface similarity, however, they are genuinely different molecules: BPC-157 is a 15-amino-acid sequence isolated from a cytoprotective fraction of human gastric juice and characterized by Predrag Sikiric and the Zagreb group, while TB-500 is a 17-amino-acid synthetic fragment of the 43-residue actin-sequestering protein Thymosin Beta-4 (T4), originally isolated from calf thymus by Allan Goldstein and colleagues

Clinical Update 1/31/2021 B12 for Diabetic Neuropathy