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The answer depends on timing

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Zrate et al., Activation of the high-affinity BDNF receptor TrkB results in phosphorylation of tyrosine residues in the cytoplasmic domain of the receptor and subsequent recruitment and activation of signaling proteins that engage extracellular signal-regulated kinases (ERKs) and the phosphatidylinositol 3-kinase (PI3K)-Akt kinase pathway (Figure 3