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While glucose is the obligatory fuel, ketone bodies can also be used by the brain when glucose supply is inadequate, such as during prolonged fasting or starvation

In this case, the UPR can activate apoptotic signalling pathways that lead to cell death [45, 46]

For example, targeting the activation of ROCK has shown some promise by attenuating myofibroblast differentiation and contractility while sparing fibroblast proliferation [171]