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(2019) showed that naringin (50 M) protects the integrity of rat intestinal microvascular endothelial cell monolayer barriers against TNF--induced disruption, preventing TNF--induced apoptosis and suppressing cell migration, and avoiding gut-vascular barrier disruption (Liu et al., 2019)

Mice with a combined deficiency of superoxide dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) develop spontaneous retinal degeneration with aging

For example, Parkin, an E3 ubiquitin ligase encoded by the PRKN gene, ubiquitinates damaged mitochondria to induce degradation and mitophagy [38], and mutations in Parkin are the most common cause of autosomal recessive early-onset PD [38]

Unbalanced glutamine partitioning between CD8T cells and cancer cells accompanied by immune cell dysfunction in hepatocellular carcinoma

and Crispe, N.J